IL12A

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[top] Gene Information

See help:GeneInfo for helping with entering information in this table.

Gene_symbol

IL12A

Gene_name

interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)

Synonyms

CLMF|ILN12A|NFSK|NKSF1|P35

Entrez_gene_ID

3592

Gene_type

protein-coding

Chromosome

3

Location

3q25.33-q26

Cancer_correlation

N

HCC_significant_gene

This gene is expressed significantly in hepatocellular carcinoma.
Source of evidence: EHCO

Liver_specific_gene
Cross_references

HGNC:5969

[top] Related Diseases

See help:RelatedDisease for helping with entering information in this table.

NamePhenotypeDetection_MethodChange_TypeAssociationConclusionReferenceConfidence

Hepatitis

Hepatitis

Text mining

Uncategorized

Unassigned

1

Liver fibrosis and liver cirrhosis

Liver fibrosis

Text mining and Manually revised

Uncategorized

Unassigned

4

Viral hepatitis

Hepatitis, Viral, Human

Text mining

Uncategorized

Unassigned

1

Hepatitis A

Hepatitis A

Text mining

Uncategorized

Unassigned

1

Hepatitis B

Hepatitis B

Text mining

Uncategorized

Unassigned

1

Chronic hepatitis B

Hepatitis B, Chronic

Text mining

Uncategorized

Unassigned

1

Hepatitis C

Hepatitis C

Text mining

Uncategorized

Unassigned

1

Chronic hepatitis C

Hepatitis C, Chronic

Text mining

Uncategorized

Unassigned

1

Hepatitis D

Hepatitis D

Text mining

Uncategorized

Unassigned

1

Hepatitis E

Hepatitis E

Text mining

Uncategorized

Unassigned

1

Chronic hepatitis

Hepatitis, Chronic

Text mining

Uncategorized

Unassigned

1

Biliary cirrhosis

BILIARY CIRRHOSIS; liver Cirrhosis, Biliary

Text mining

Uncategorized

Unassigned

1

Hepatocellular carcinoma

Hepatocellular carcinoma

Gene microarray

Down-regulated at mRNA level

Yes

4

Primary biliary cirrhosis

primary biliary cirrhosis

Text mining

Uncategorized

Unassigned

1


[top] Related Proteins

See help:RelatedProtein for helping with entering information in this table.

Uniprot_IDProtein_name Subcellular_localizationReferences

IL12A_HUMAN

Interleukin-12 subunit alpha

Secreted.

http://www.ncbi.nlm.nih.gov/protein/NP_000873

O60595_HUMAN

Interleukin 12

http://www.ncbi.nlm.nih.gov/protein/NP_000873

[top] Gene Ontology

See help:GeneOntology for helping with entering information in this table.

GO_IDNameSourceWebsite

GO:0001916

positive regulation of T cell mediated cytotoxicity

GO:0002860

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

GO:0005125

cytokine activity

GO:0005143

interleukin-12 receptor binding

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0005737

cytoplasm

GO:0006955

immune response

GO:0007050

cell cycle arrest

GO:0008083

growth factor activity

GO:0009615

response to virus

GO:0010224

response to UV-B

GO:0016477

cell migration

GO:0032496

response to lipopolysaccharide

GO:0032700

negative regulation of interleukin-17 production

GO:0032729

positive regulation of interferon-gamma production

GO:0032816

positive regulation of natural killer cell activation

GO:0034393

positive regulation of smooth muscle cell apoptosis

GO:0042102

positive regulation of T cell proliferation

GO:0042163

interleukin-12 beta subunit binding

GO:0042520

positive regulation of tyrosine phosphorylation of Stat4 protein

GO:0042832

defense response to protozoan

GO:0043514

interleukin-12 complex

GO:0045513

interleukin-27 binding

GO:0045785

positive regulation of cell adhesion

GO:0045954

positive regulation of natural killer cell mediated cytotoxicity

GO:0046982

protein heterodimerization activity

GO:0048662

negative regulation of smooth muscle cell proliferation

GO:0050671

positive regulation of lymphocyte proliferation

GO:0050830

defense response to Gram-positive bacterium

GO:0051135

positive regulation of NK T cell activation


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