IL12A
From LiverWiki
Contents |
[top] Gene Information
See help:GeneInfo for helping with entering information in this table.
Gene_symbol |
IL12A |
---|---|
Gene_name |
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) |
Synonyms |
CLMF|ILN12A|NFSK|NKSF1|P35 |
Entrez_gene_ID | |
Gene_type |
protein-coding |
Chromosome |
3 |
Location |
3q25.33-q26 |
Cancer_correlation |
N |
HCC_significant_gene |
This gene is expressed significantly in hepatocellular carcinoma. |
Liver_specific_gene | |
Cross_references | |
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[top] Related Diseases
See help:RelatedDisease for helping with entering information in this table.
Name | Phenotype | Detection_Method | Change_Type | Association | Conclusion | Reference | Confidence |
---|---|---|---|---|---|---|---|
Hepatitis |
Text mining |
Uncategorized |
Unassigned |
1 | |||
Liver fibrosis |
Text mining and Manually revised |
Uncategorized |
Unassigned |
4 | |||
Hepatitis, Viral, Human |
Text mining |
Uncategorized |
Unassigned |
1 | |||
Hepatitis A |
Text mining |
Uncategorized |
Unassigned |
1 | |||
Hepatitis B |
Text mining |
Uncategorized |
Unassigned |
1 | |||
Hepatitis B, Chronic |
Text mining |
Uncategorized |
Unassigned |
1 | |||
Hepatitis C |
Text mining |
Uncategorized |
Unassigned |
1 | |||
Hepatitis C, Chronic |
Text mining |
Uncategorized |
Unassigned |
1 | |||
Hepatitis D |
Text mining |
Uncategorized |
Unassigned |
1 | |||
Hepatitis E |
Text mining |
Uncategorized |
Unassigned |
1 | |||
Hepatitis, Chronic |
Text mining |
Uncategorized |
Unassigned |
1 | |||
BILIARY CIRRHOSIS; liver Cirrhosis, Biliary |
Text mining |
Uncategorized |
Unassigned |
1 | |||
Hepatocellular carcinoma |
Gene microarray |
Down-regulated at mRNA level |
Yes |
4 | |||
primary biliary cirrhosis |
Text mining |
Uncategorized |
Unassigned |
1
| |||
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[top] Related Proteins
See help:RelatedProtein for helping with entering information in this table.
Uniprot_ID | Protein_name | Subcellular_localization | References |
---|---|---|---|
Interleukin-12 subunit alpha |
Secreted. | ||
Interleukin 12 | |||
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[top] Gene Ontology
See help:GeneOntology for helping with entering information in this table.
GO_ID | Name | Source | Website |
---|---|---|---|
GO:0001916 |
positive regulation of T cell mediated cytotoxicity | ||
GO:0002860 |
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | ||
GO:0005125 |
cytokine activity | ||
GO:0005143 |
interleukin-12 receptor binding | ||
GO:0005515 |
protein binding | ||
GO:0005576 |
extracellular region | ||
GO:0005615 |
extracellular space | ||
GO:0005737 |
cytoplasm | ||
GO:0006955 |
immune response | ||
GO:0007050 |
cell cycle arrest | ||
GO:0008083 |
growth factor activity | ||
GO:0009615 |
response to virus | ||
GO:0010224 |
response to UV-B | ||
GO:0016477 |
cell migration | ||
GO:0032496 |
response to lipopolysaccharide | ||
GO:0032700 |
negative regulation of interleukin-17 production | ||
GO:0032729 |
positive regulation of interferon-gamma production | ||
GO:0032816 |
positive regulation of natural killer cell activation | ||
GO:0034393 |
positive regulation of smooth muscle cell apoptosis | ||
GO:0042102 |
positive regulation of T cell proliferation | ||
GO:0042163 |
interleukin-12 beta subunit binding | ||
GO:0042520 |
positive regulation of tyrosine phosphorylation of Stat4 protein | ||
GO:0042832 |
defense response to protozoan | ||
GO:0043514 |
interleukin-12 complex | ||
GO:0045513 |
interleukin-27 binding | ||
GO:0045785 |
positive regulation of cell adhesion | ||
GO:0045954 |
positive regulation of natural killer cell mediated cytotoxicity | ||
GO:0046982 |
protein heterodimerization activity | ||
GO:0048662 |
negative regulation of smooth muscle cell proliferation | ||
GO:0050671 |
positive regulation of lymphocyte proliferation | ||
GO:0050830 |
defense response to Gram-positive bacterium | ||
GO:0051135 |
positive regulation of NK T cell activation |
| |
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